Attracting stem cells and facilitating bone regeneration by adhesive
protein

Date:
March 13, 2023
Source:
Pohang University of Science & Technology (POSTECH)
Summary:
Scientists have developed an osteogenic barrier coating material
that maximizes the effect of guided bone regeneration (GBR) for
implant placements.


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FULL STORY ==========================================================================
One of the key factors of success in a dental implant is the condition
of the periodontium around the implant. A higher long-term success rate
of dental implants requires sufficient and healthy alveolar bone. In
those cases where lack of alveolar bone renders setting an implant
difficult, the bone should be regenerated sufficiently to receive the
implant, whether before or during the implant surgery. Development of osteogenic barrier coating material for implants by a Korean research
team is expected to improve the success rate of alveolar bone grafting.


========================================================================== Three research teams led by Professor Hyung Joon Cha of the Chemical Engineering Department at Pohang University of Science and Technology (POSTECH), Professor Yun Kee Jo of the School of Convergence at Kyungpook National University (KNU), and Professor Sang Ho Jun of the Department of
Oral and Maxillofacial Surgery at Korea University Anam Hospital together developed an osteogenic barrier coating material for dental implants that prevents the invasion of soft tissue cells, attracts osteo-progenitor
cells including bone stem cells, and sustainably releases the loaded
bone morphogenetic protein-2 (BMP-2), significantly facilitating bone regeneration.

GBR is widely used in dental implant placement. It maintains the space
for bones to grow and prevents cells other than osteogenic cells, such
as fibroblasts, from populating the bone defect sites, allowing the
bone to grow without interference by non-osteogenic cells. However, the
GBR approach is still less likely to be successful and requires longer treatment time for those patients with insufficient bone quantity and
quality. Depending on the configurations of defect sites, preventing the invasion of the non-osteogenic cells by using barrier membranes alone
is not enough to significantly facilitate the bone regeneration.

The joint research team first loaded BMP-2 on top of the bioengineered
material where RGD peptide, cell recognitive motif that is capable
of attracting cells, is fused with mussel adhesive protein (MAP) that
maintains strong adhesiveness in a wet environment. The team then coated
the titanium mesh (Ti-mesh) membrane with it. According to the research findings, the coated barrier membrane exhibited cell occlusivity where fibroblasts could not permeate the membrane.

The team also found that it induced a high level of bone differentiation
in a short period of time inside the membrane by means of high growth
of mesenchymal stem cells and release of BMP-2.

Application of the developed MAP-based barrier coating for guided bone regeneration to a titanium membrane in a rat calvarial defect model showed
that the coating roughly doubled the speed of bone tissue regeneration.

Professor Hyung Joon Cha who led the research said, "This research
was conducted based on long-term research cooperation of the joint
research team in the area of bone regeneration for implant placement. Its findings revealed the possibility of improving the success rate of implant treatment regardless of the bone condition." He added that the research findings could also be applied to regenerate a variety of hard tissues.

The research findings were published in the online edition of the Bioengineering & Translational Medicine, a distinguished journal in
the field of bioengineering and regenerative medicine. The study was
conducted as a part of the Dentistry Technology R&D Project under the
Korea Health Technology R&D Project funded by the Ministry of Health &
Welfare, the High Value-added Food Technology Development Program funded
by the Ministry of Agriculture, Food & Rural Affairs, and the BK21 Four
Program by the National Research Foundation of Korea.

* RELATED_TOPICS
o Health_&_Medicine
# Osteoporosis # Bone_and_Spine # Stem_Cells # Leukemia
o Matter_&_Energy
# Biochemistry # Organic_Chemistry # Medical_Technology
# Engineering
* RELATED_TERMS
o Bone_scan o Bone_marrow o Photoelectric_effect o Osteoporosis
o Triboelectric_effect o Peripheral_nervous_system o
Bone_fracture o Breast_implant

========================================================================== Story Source: Materials provided by Pohang_University_of_Science_&_Technology_(POSTECH).

Note: Content may be edited for style and length.


========================================================================== Journal Reference:
1. Yun Kee Jo, Bong‐Hyuk Choi, Cong Zhou, Sang Ho Jun, Hyung
Joon Cha.

Cell recognitive bioadhesive‐based osteogenic barrier coating
with localized delivery of bone morphogenetic protein‐2 for
accelerated guided bone regeneration. Bioengineering & Translational
Medicine, 2023; DOI: 10.1002/btm2.10493 ==========================================================================

Link to news story: https://www.sciencedaily.com/releases/2023/03/230313215106.htm

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