'Second-guessing' is a hard-wired behavior

Date:
May 24, 2023
Source:
University of Utah Health
Summary:
Have you ever made a decision that, in hindsight, seemed
irrational? A new study with mice, which could have implications
for people, suggests that some decisions are, to a certain extent,
beyond their control.

Rather, the mice are hard-wired to make them.


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FULL STORY ==========================================================================
Have you ever made a decision that, in hindsight, seemed irrational? A new study with mice, which could have implications for people, suggests that
some decisions are, to a certain extent, beyond their control. Rather,
the mice are hard-wired to make them.

"This research is telling us that animals are constrained in the decisions
they make," says Christopher Gregg, PhD, a neurobiologist at University
of Utah Health and senior author of the study that recently published
in iScience.

"Their genetics push them down one path or another." Gregg and his
research team started investigating decision-making after noticing mice repeatedly making what appeared to be an irrational decision.

After finding a stash of hidden seeds, rather than staying put to eat
them, mice kept returning to a location that had food in it the day
before. Only on this day, the original location was empty.

"It was as if the mice were second-guessing whether the first location
really had no food," Gregg says. "Like they thought they had missed
something." To Gregg and the study's co-authors, the behavior didn't
make any sense. The animals ended up eating less because of the time
spent continuously returning to the empty food patch. If that kind of
behavior causes mice to eat less in the wild, it could spell trouble,
Gregg explains, because not getting enough calories can be detrimental
for a mouse.

The real surprise came after discovering that mice lacking a specific gene didn't "second-guess" where to go and instead were more likely to stay
and eat the food they found. As a result, they consumed more calories
overall. This was the first evidence the scientists found that genes
could bias decision-making, even decisions that did not seem logical,
at least to a human. In this case, the gene Arc appeared to be important
for compelling the mice to continue searching for food even when it
didn't appear to be necessary.

"We all have a clear sense of what it is like to second-guess something,
but who would have thought that this type of behavior could be so
profoundly affected by one gene?" says Cornelia Stacher- Ho"rndli,
PhD, neurobiologist and co-author. "This raises the question, are other cognitive biases under genetic control?" Decoding behavior To the human
eye, a mouse's life seems pretty simple. When placed in a naturalistic
setting in Gregg's lab, they left home, explored their surroundings,
searched for food, ate a little, and made stops back home in between. But
the view looked quite different after a machine learning algorithm deconstructed their journeys.

A custom program built by Gregg and study co-author Jared Emery analyzed
1,609 foraging excursions and saw that the mice repeated 24 behavior
sequences over and over. As the mice foraged, they strung together the sequences like building blocks, interspersing them with spontaneous
behaviors to construct more complex behavior patterns. One of them was
the second-guessing behavior. "To a certain extent, you could predict
the future," Gregg remarks.

That future changed for mice missing the gene, Arc. Six of the 24 behavior sequences were altered, and together, those differences short-circuited
the second-guessing behavior. Previous research had shown Arc is
involved in learning and memory. But overall, analysis showed that the
mice's memory -- and their other behaviors -- were largely intact. The implication is that the effect on those six behaviors was specific.

"One intriguing idea is that the animals evolved to make those decisions because they were somehow advantageous in the wild," Gregg says. He
explains one possibility: when mice go back and forth to evaluate previous
food locations, it helps them create a mental map. And that might help
them find food faster the next time around. "Genetically controlled
cognitive bias may allow for effective decision-making during foraging,"
he says.

The question remains, is there a biological basis for other types of
cognitive bias? And could genes guide decision-making in humans? More
research will tell.

"I believe that this research is foundational for a new field that we
are calling 'decision genetics,'" Stacher-Ho"rndli says.

* RELATED_TOPICS
o Mind_&_Brain
# Behavior # Consumer_Behavior # Huntington's_Disease #
Psychology # Nutrition_Research # Social_Psychology #
Psychiatry # Child_Development
* RELATED_TERMS
o Illusion_of_control o Microeconomics o Psycholinguistics
o Macroeconomics o Thought o Social_psychology o
Anchoring_bias_in_decision-making o Culture_of_fear

========================================================================== Story Source: Materials provided by University_of_Utah_Health. Note:
Content may be edited for style and length.


========================================================================== Journal Reference:
1. Alicia Ravens, Cornelia N. Stacher-Ho"rndli, Jared Emery, Susan
Steinwand, Jason D. Shepherd, Christopher Gregg. Arc regulates
a second- guessing cognitive bias during naturalistic foraging
through effects on discrete behavior modules. iScience, 2023; 26
(5): 106761 DOI: 10.1016/ j.isci.2023.106761 ==========================================================================

Link to news story: https://www.sciencedaily.com/releases/2023/05/230524181833.htm

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